5JZJ

Crystal structure of DCLK1-KD in complex with AMPPN

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Serine/threonine-protein kinase DCLK1	polymer	297	33475.1	2	UniProt (O15075) Pfam (PF00069)	Homo sapiens (Human)	Doublecortin domain-containing protein 3A,Doublecortin-like and CAM kinase-like 1,Doublecortin-like kinase 1
2	C, F (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
3	D (A)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
4	E, G (A, B)	AMP PHOSPHORAMIDATE	non-polymer		426.2	2	Chemie (AN2)
5	H, I (A, B)	water	water		18.0	493	Chemie (HOH)

Sequence modifications

A, B: 372 - 649 (UniProt: O15075)

PDB	External Database	Details
Met 353	-	initiating methionine
His 354	-	expression tag
His 355	-	expression tag
His 356	-	expression tag
His 357	-	expression tag
His 358	-	expression tag
His 359	-	expression tag
His 360	-	expression tag
His 361	-	expression tag
Gly 362	-	expression tag
Ser 363	-	expression tag
Glu 364	-	expression tag
Asn 365	-	expression tag
Leu 366	-	expression tag
Tyr 367	-	expression tag
Phe 368	-	expression tag
Gln 369	-	expression tag
Gly 370	-	expression tag
Ser 371	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	66950.2
Non-Polymers*	Number of molecules	5
	Total formula weight	997.1
All*	Total formula weight	67947.3

*Water molecules are not included.