5JUZ
Crystal structure of human FPPS in complex with an allosteric inhibitor CL-06-057
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | F | Farnesyl pyrophosphate synthase | polymer | 375 | 43145.0 | 1 | UniProt (P14324) Pfam (PF00348) In PDB | Homo sapiens (Human) | FPS,(2E,6E)-farnesyl diphosphate synthase,Dimethylallyltranstransferase,Farnesyl diphosphate synthase,Geranyltranstransferase |
2 | F | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
3 | F | [(R)-(2,3-dihydro-1-benzofuran-5-yl){[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}methyl]phosphonic acid | non-polymer | 453.5 | 1 | Chemie (YL4) | |||
4 | water | water | 18.0 | 95 | Chemie (HOH) |
Sequence modifications
F: 1 - 353 (UniProt: P14324)
PDB | External Database | Details |
---|---|---|
Met -21 | - | initiating methionine |
Gly -20 | - | expression tag |
Ser -19 | - | expression tag |
Ser -18 | - | expression tag |
His -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
Ser -11 | - | expression tag |
Ser -10 | - | expression tag |
Gly -9 | - | expression tag |
Arg -8 | - | expression tag |
Glu -7 | - | expression tag |
Asn -6 | - | expression tag |
Leu -5 | - | expression tag |
Tyr -4 | - | expression tag |
Phe -3 | - | expression tag |
Gln -2 | - | expression tag |
Gly -1 | - | expression tag |
His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 43145.0 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 524.4 | |
All* | Total formula weight | 43669.3 |