5JKD

Crystal structure of human IZUMO1-JUNO complex (crystal form 2)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Izumo sperm-egg fusion protein 1	polymer	246	28163.3	1	UniProt (Q8IYV9) Pfam (PF15005) Pfam (PF16706)	Homo sapiens (Human)	Oocyte binding/fusion factor,OBF,Sperm-specific protein izumo
2	B (B)	Sperm-egg fusion protein Juno	polymer	221	25428.8	1	UniProt (A6ND01) Pfam (PF03024)	Homo sapiens (Human)	Folate receptor 4,Folate receptor delta,FR-delta,IZUMO1 receptor protein JUNO
3	C, D (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
4	E (B)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
5	F (A)	water	water		18.0	3	Chemie (HOH)

Sequence modifications

A: 22 - 255 (UniProt: Q8IYV9)

PDB	External Database	Details
Arg 18	-	expression tag
Ser 19	-	expression tag
Pro 20	-	expression tag
Trp 21	-	expression tag
Glu 256	-	expression tag
Phe 257	-	expression tag
Leu 258	-	expression tag
Glu 259	-	expression tag
Val 260	-	expression tag
Leu 261	-	expression tag
Phe 262	-	expression tag
Gln 263	-	expression tag

B: 20 - 228 (UniProt: A6ND01)

PDB	External Database	Details
Arg 16	-	expression tag
Ser 17	-	expression tag
Pro 18	-	expression tag
Trp 19	-	expression tag
Glu 229	-	expression tag
Phe 230	-	expression tag
Leu 231	-	expression tag
Glu 232	-	expression tag
Val 233	-	expression tag
Leu 234	-	expression tag
Phe 235	-	expression tag
Gln 236	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	53592.2
Non-Polymers*	Number of molecules	3
	Total formula weight	477.9
All*	Total formula weight	54070.0

*Water molecules are not included.