5JIH

Crystal structure of HER2 binding IgG1-Fc (Fcab STAB19)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Ig gamma-1 chain C region	polymer	227	25567.9	2	UniProt (P01857) Pfam (PF07654)	Homo sapiens (Human)	Fcab STAB19
2	C (C)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1463.3	1	In PDB GlyTouCan (G80858MF)
3	D (D)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1114.0	1	In PDB GlyTouCan (G64481DJ)
4	E, F (A, B)	water	water		18.0	230	Chemie (HOH)

Sequence modifications

A, B: 225 - 446 (UniProt: P01857)

PDB	External Database	Details
Tyr 358	Leu 241	engineered mutation
Leu 359	Thr 242	engineered mutation
Ser 360	Lys 243	engineered mutation
Asp 361	Asn 244	engineered mutation
Ser 362	Gln 245	engineered mutation
Pro 413	Asp 246	engineered mutation
Arg 414	Lys 247	engineered mutation
His 415	Ser 248	engineered mutation
Ser 415	-	insertion
Glu 415	-	insertion
Thr 415	-	insertion
Met 415	-	insertion
Arg 415	-	insertion
Ala 418	Gln 301	engineered mutation
His 419	Gln 302	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	51135.8
Branched	Number of molecules	2
	Total formula weight	2577.4
All*	Total formula weight	53713.2

*Water molecules are not included.