5JHU
Potent, Reversible MetAP2 Inhibitors via FBDD
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Methionine aminopeptidase 2 | polymer | 369 | 41356.0 | 1 | UniProt (P50579) Pfam (PF00557) In PDB | Homo sapiens (Human) | MetAP 2,Initiation factor 2-associated 67 kDa glycoprotein,p67eIF2,Peptidase M |
| 2 | A | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 3 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 5 | A | [(2R)-1-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)pyrrolidin-2-yl]methyl 2-methoxybenzoate | non-polymer | 353.4 | 1 | Chemie (6KO) | |||
| 6 | water | water | 18.0 | 313 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41356.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 633.5 | |
| All* | Total formula weight | 41989.5 |
