5JFW

Crystal structure of TrkA in complex with PF-05247452

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	High affinity nerve growth factor receptor	polymer	308	35101.6	1	UniProt (P04629) Pfam (PF07714)	Homo sapiens (Human)	Neurotrophic tyrosine kinase receptor type 1,TRK1-transforming tyrosine kinase protein,Tropomyosin-related kinase A,Tyrosine kinase receptor A,Trk-A,gp140trk,p140-TrkA
2	B (A)	2-(4-cyanophenyl)-N-{5-[7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl}acetamide	non-polymer		424.5	1	Chemie (6K2)
3	C (A)	water	water		18.0	429	Chemie (HOH)

Sequence modifications

A: 502 - 796 (UniProt: P04629)

PDB	External Database	Details
Met 489	-	initiating methionine
His 490	-	expression tag
His 491	-	expression tag
His 492	-	expression tag
His 493	-	expression tag
His 494	-	expression tag
His 495	-	expression tag
Leu 496	-	expression tag
Val 497	-	expression tag
Pro 498	-	expression tag
Arg 499	-	expression tag
Gly 500	-	expression tag
Ser 501	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	35101.6
Non-Polymers*	Number of molecules	1
	Total formula weight	424.5
All*	Total formula weight	35526.0

*Water molecules are not included.