5JDU
Crystal structure for human thrombin mutant D189A
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Thrombin light chain | polymer | 33 | 3791.2 | 2 | UniProt (P00734) Pfam (PF09396) In PDB | Homo sapiens (Human) | Coagulation factor II |
2 | B, D | Thrombin heavy chain | polymer | 259 | 29736.2 | 2 | UniProt (P00734) Pfam (PF00089) In PDB | Homo sapiens (Human) | Coagulation factor II |
3 | E, F | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G35932AR) | |||
4 | D | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
5 | D | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
6 | water | water | 18.0 | 622 | Chemie (HOH) |
Sequence modifications
B, D: 16 - 247 (UniProt: P00734)
PDB | External Database | Details |
---|---|---|
Ala 189 | Asp 562 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 67054.8 | |
Branched | Number of molecules | 2 |
Total formula weight | 848.8 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 127.5 | |
All* | Total formula weight | 68031.2 |