5JDU
Crystal structure for human thrombin mutant D189A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Thrombin light chain | polymer | 33 | 3791.2 | 2 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (Human) | Coagulation factor II |
| 2 | B, D (B, D) | Thrombin heavy chain | polymer | 259 | 29736.2 | 2 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (Human) | Coagulation factor II |
| 3 | E, F (E, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G35932AR) | |||
| 4 | G (D) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | H (D) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 622 | Chemie (HOH) |
Sequence modifications
B, D: 16 - 247 (UniProt: P00734)
| PDB | External Database | Details |
|---|---|---|
| Ala 189 | Asp 562 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 67054.8 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 848.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 127.5 | |
| All* | Total formula weight | 68031.2 |
