5JB8
Crystal structure of factor IXa variant K98T in complex with EGR-chloromethylketone
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | E | Coagulation factor IX | polymer | 58 | 6395.3 | 1 | UniProt (P00740) Pfam (PF14670) In PDB | Homo sapiens (Human) | Christmas factor,Plasma thromboplastin component,PTC |
| 2 | S | Coagulation factor IX | polymer | 235 | 26162.7 | 1 | UniProt (P00740) Pfam (PF00089) In PDB | Homo sapiens (Human) | Christmas factor,Plasma thromboplastin component,PTC |
| 3 | S | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 4 | S | L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide | non-polymer | 395.9 | 1 | BIRD (PRD_000288) Chemie (0GJ) | |||
| 5 | S | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 6 | water | water | 18.0 | 254 | Chemie (HOH) |
Sequence modifications
S: 16 - 245 (UniProt: P00740)
| PDB | External Database | Details |
|---|---|---|
| Thr 98 | Lys 311 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 32558.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 514.1 | |
| All* | Total formula weight | 33072.1 |
