5JAL
Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered Through X-Ray Fragment Screening
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Platelet-activating factor acetylhydrolase | polymer | 388 | 44203.1 | 1 | UniProt (Q13093) Pfam (PF03403) | Homo sapiens (Human) | PAF acetylhydrolase,1-alkyl-2-acetylglycerophosphocholine esterase,2-acetyl-1-alkylglycerophosphocholine esterase,Group-VIIA phospholipase A2,gVIIA-PLA2,LDL-associated phospholipase A2,LDL-PLA(2),PAF 2-acylhydrolase |
| 2 | B (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 3 | C, D (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 4 | E (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 5 | F (A) | (2,5-dihydro-1H-pyrrol-1-yl)(3-fluorophenyl)methanone | non-polymer | 191.2 | 1 | Chemie (6HO) | |||
| 6 | G (A) | water | water | 18.0 | 342 | Chemie (HOH) |
Sequence modifications
A: 46 - 428 (UniProt: Q13093)
| PDB | External Database | Details |
|---|---|---|
| His 429 | - | expression tag |
| His 430 | - | expression tag |
| His 431 | - | expression tag |
| His 432 | - | expression tag |
| His 433 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 44203.1 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 364.5 | |
| All* | Total formula weight | 44567.7 |
