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5JAD

Compound binding to Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2)discovered through fragment screening

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1APlatelet-activating factor acetylhydrolasepolymer38844203.11UniProt (Q13093)
Pfam (PF03403)
In PDB
Homo sapiens (Human)PAF acetylhydrolase,1-alkyl-2-acetylglycerophosphocholine esterase,2-acetyl-1-alkylglycerophosphocholine esterase,Group-VIIA phospholipase A2,gVIIA-PLA2,LDL-associated phospholipase A2,LDL-PLA(2),PAF 2-acylhydrolase
2AMAGNESIUM IONnon-polymer24.31Chemie (MG)
3ACHLORIDE IONnon-polymer35.51Chemie (CL)
4ADIMETHYL SULFOXIDEnon-polymer78.11Chemie (DMS)
5Abenzenesulfonamidenon-polymer157.21Chemie (FB2)
6waterwater18.0143Chemie (HOH)
Sequence modifications
A: 46 - 428 (UniProt: Q13093)
PDBExternal DatabaseDetails
His 429-expression tag
His 430-expression tag
His 431-expression tag
His 432-expression tag
His 433-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight44203.1
Non-Polymers*Number of molecules4
Total formula weight295.1
All*Total formula weight44498.2
*Water molecules are not included.

224201

PDB entries from 2024-08-28

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