5J9Z
EGFR-T790M in complex with pyrazolopyrimidine inhibitor 1a
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Epidermal growth factor receptor | polymer | 325 | 37149.0 | 1 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | A | (R)-1-(3-(4-amino-3-(1-methyl-1H-indol-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one | non-polymer | 401.5 | 1 | Chemie (6HJ) | |||
| 3 | water | water | 18.0 | 21 | Chemie (HOH) |
Sequence modifications
A: 696 - 1020 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Met 790 | Thr 790 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37149.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 401.5 | |
| All* | Total formula weight | 37550.5 |
