5J9F

Human GAR transformylase in complex with GAR and (4-{[2-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)ethyl]amino}benzoyl)-L-glutamic acid (AGF183)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Trifunctional purine biosynthetic protein adenosine-3	polymer	210	22753.1	1	UniProt (P22102) Pfam (PF00551) In PDB	Homo sapiens (Human)
2	A	GLYCINAMIDE RIBONUCLEOTIDE	non-polymer		284.2	1	Chemie (GAR)
3	A	N-(4-{[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)ethyl]amino}benzene-1-carbonyl)-L-glutamic acid	non-polymer		442.4	1	Chemie (83A)
4		water	water		18.0	52	Chemie (HOH)

Sequence modifications

A: 808 - 1010 (UniProt: P22102)

PDB	External Database	Details
Met 807	-	initiating methionine
Ala 905	Gln 905	engineered mutation
His 1011	-	expression tag
His 1012	-	expression tag
His 1013	-	expression tag
His 1014	-	expression tag
His 1015	-	expression tag
His 1016	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	22753.1
Non-Polymers*	Number of molecules	2
	Total formula weight	726.6
All*	Total formula weight	23479.7

*Water molecules are not included.