5J8M
Crystal Structure of Hsp90-alpha N-domain L107A mutant in complex with 5-(5-Bromo-2,4-dihydroxy-phenyl)-4-(2-fluoro-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Heat shock protein HSP 90-alpha | polymer | 225 | 25285.4 | 2 | UniProt (P07900) Pfam (PF13589) In PDB | Homo sapiens (Human) | Heat shock 86 kDa,HSP86,Lipopolysaccharide-associated protein 2,LPS-associated protein 2,Renal carcinoma antigen NY-REN-38 |
| 2 | A, B | 5-(5-Bromo-2,4-dihydroxy-phenyl)-4-(2-fluoro-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one | non-polymer | 366.1 | 2 | Chemie (6DL) | |||
| 3 | water | water | 18.0 | 366 | Chemie (HOH) |
Sequence modifications
A, B: 9 - 233 (UniProt: P07900)
| PDB | External Database | Details |
|---|---|---|
| Ala 107 | Leu 229 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 50570.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 732.3 | |
| All* | Total formula weight | 51303.1 |
