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5J8I

Crystal structure of TL11-113 bound to TAK1-TAB1

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Mitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 chimerapolymer31435463.91UniProt (O43318)
UniProt (Q15750)
Pfam (PF07714)
Homo sapiens (Human)Transforming growth factor-beta-activated kinase 1,TGF-beta-activated kinase 1,Mitogen-activated protein kinase kinase kinase 7-interacting protein 1,TGF-beta-activated kinase 1-binding protein 1,TAK1-binding protein 1
2B
(A)
N-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamidenon-polymer464.91Chemie (6H4)
Sequence modifications
A: 31 - 303 (UniProt: O43318)
PDBExternal DatabaseDetails
Ser 27-expression tag
Leu 28-expression tag
His 29-expression tag
Met 30-expression tag
A: 468 - 504 (UniProt: Q15750)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight35463.9
Non-Polymers*Number of molecules1
Total formula weight464.9
All*Total formula weight35928.8
*Water molecules are not included.

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PDB entries from 2025-07-23

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