5J8F

Human MOF K274P crystal structure

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Histone acetyltransferase KAT8	polymer	307	36065.4	1	UniProt (Q9H7Z6) Pfam (PF17772) Pfam (PF01853)	Homo sapiens (Human)	Lysine acetyltransferase 8,MOZ,YBF2/SAS3,SAS2 and TIP60 protein 1,hMOF
2	B (A)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
3	C, D (A)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
4	E (A)	water	water		18.0	19	Chemie (HOH)

Sequence modifications

A: 177 - 458 (UniProt: Q9H7Z6)

PDB	External Database	Details
Met 152	-	initiating methionine
Gly 153	-	expression tag
Ser 154	-	expression tag
Ser 155	-	expression tag
His 156	-	expression tag
His 157	-	expression tag
His 158	-	expression tag
His 159	-	expression tag
His 160	-	expression tag
His 161	-	expression tag
Asp 162	-	expression tag
Tyr 163	-	expression tag
Asp 164	-	expression tag
Ile 165	-	expression tag
Pro 166	-	expression tag
Thr 167	-	expression tag
Thr 168	-	expression tag
Glu 169	-	expression tag
Asn 170	-	expression tag
Leu 171	-	expression tag
Tyr 172	-	expression tag
Phe 173	-	expression tag
Gln 174	-	expression tag
Gly 175	-	expression tag
Ser 176	-	expression tag
Pro 274	Lys 274	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36065.4
Non-Polymers*	Number of molecules	3
	Total formula weight	136.3
All*	Total formula weight	36201.7

*Water molecules are not included.