5J8C

Human MOF C316S, E350Q crystal structure

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Histone acetyltransferase KAT8	polymer	307	36121.5	1	UniProt (Q9H7Z6) Pfam (PF17772) Pfam (PF01853) In PDB	Homo sapiens (Human)	Lysine acetyltransferase 8,MOZ,YBF2/SAS3,SAS2 and TIP60 protein 1,hMOF
2	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
3	A	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
4	A	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
5		water	water		18.0	77	Chemie (HOH)

Sequence modifications

A: 177 - 458 (UniProt: Q9H7Z6)

PDB	External Database	Details
Met 152	-	initiating methionine
Gly 153	-	expression tag
Ser 154	-	expression tag
Ser 155	-	expression tag
His 156	-	expression tag
His 157	-	expression tag
His 158	-	expression tag
His 159	-	expression tag
His 160	-	expression tag
His 161	-	expression tag
Asp 162	-	expression tag
Tyr 163	-	expression tag
Asp 164	-	expression tag
Ile 165	-	expression tag
Pro 166	-	expression tag
Thr 167	-	expression tag
Thr 168	-	expression tag
Glu 169	-	expression tag
Asn 170	-	expression tag
Leu 171	-	expression tag
Tyr 172	-	expression tag
Phe 173	-	expression tag
Gln 174	-	expression tag
Gly 175	-	expression tag
Ser 176	-	expression tag
Ser 316	Cys 316	engineered mutation
Gln 350	Glu 350	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36121.5
Non-Polymers*	Number of molecules	5
	Total formula weight	182.3
All*	Total formula weight	36303.8

*Water molecules are not included.