5J71
Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PS35
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | polymer | 400 | 45233.4 | 1 | UniProt (Q15119) Pfam (PF10436) Pfam (PF02518) | Homo sapiens (Human) | Pyruvate dehydrogenase kinase isoform 2,PDKII |
| 2 | B (A) | L(+)-TARTARIC ACID | non-polymer | 150.1 | 1 | Chemie (TLA) | |||
| 3 | C (A) | 4-({5-[(piperidin-4-yl)amino]-1,3-dihydro-2H-isoindol-2-yl}sulfonyl)benzene-1,3-diol | non-polymer | 389.5 | 1 | Chemie (P35) | |||
| 4 | D (A) | water | water | 18.0 | 238 | Chemie (HOH) |
Sequence modifications
A: 9 - 407 (UniProt: Q15119)
| PDB | External Database | Details |
|---|---|---|
| Ser 8 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 45233.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 539.6 | |
| All* | Total formula weight | 45773.0 |
