5J6A
Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PS46
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | polymer | 400 | 45233.4 | 1 | UniProt (Q15119) Pfam (PF10436) Pfam (PF02518) In PDB | Homo sapiens (Human) | Pyruvate dehydrogenase kinase isoform 2,PDKII |
| 2 | A | (3S)-3-amino-4-[4-({2-[(2,4-dihydroxyphenyl)sulfonyl]-2H-isoindol-5-yl}amino)piperidin-1-yl]-4-oxobutanamide | non-polymer | 501.6 | 1 | Chemie (P46) | |||
| 3 | water | water | 18.0 | 109 | Chemie (HOH) |
Sequence modifications
A: 9 - 407 (UniProt: Q15119)
| PDB | External Database | Details |
|---|---|---|
| Ser 8 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 45233.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 501.6 | |
| All* | Total formula weight | 45735.0 |
