5J1E
Crystal Structure of a Hydroxypyridone Carboxylic Acid Active-Site RNase H Inhibitor in Complex with HIV Reverse Transcriptase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | HIV-1 REVERSE TRANSCRIPTASE P66 DOMAIN | polymer | 557 | 64105.4 | 2 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) | Pr160Gag-Pol |
| 2 | B, D (B, D) | HIV-1 REVERSE TRANSCRIPTASE P51 DOMAIN | polymer | 429 | 50096.5 | 2 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) | Pr160Gag-Pol |
| 3 | E, F, G (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 4 | H (C) | 5-hydroxy-4-oxo-1-[(4'-sulfamoyl[1,1'-biphenyl]-4-yl)methyl]-1,4-dihydropyridine-3-carboxylic acid | non-polymer | 400.4 | 1 | Chemie (6FT) | |||
| 5 | I, J (B, D) | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 555 (UniProt: P03366)
B, D: 1 - 428 (UniProt: P03366)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | initiating methionine |
| Val 0 | - | expression tag |
| Ser 280 | Cys 879 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Ser 280 | Cys 879 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 228404.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 473.3 | |
| All* | Total formula weight | 228877.3 |
