5J06

Structure of the immune receptor CD33 in complex with 3'-sialyllactose

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Myeloid cell surface antigen CD33	polymer	224	25052.1	4	UniProt (P20138) Pfam (PF07686) Pfam (PF00047)	Homo sapiens (Human)	Sialic acid-binding Ig-like lectin 3,Siglec-3,gp67
2	E (E)	N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose	branched		471.4	1	In PDB GlyTouCan (G30207PZ)
3	F, G, H, I, J... (A, B, C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	13	Chemie (NAG)
4	M, Q (B, C)	2-(2-METHOXYETHOXY)ETHANOL	non-polymer		120.1	2	Chemie (PG0)
5	U (D)	N-acetyl-alpha-neuraminic acid	non-polymer		309.3	1	Chemie (SIA)
6	V, W, X, Y (A, B, C, D)	water	water		18.0	36	Chemie (HOH)

Sequence modifications

A, B, C, D: 21 - 232 (UniProt: P20138)

PDB	External Database	Details
Glu 18	-	expression tag
Thr 19	-	expression tag
Gly 20	-	expression tag
Gly 69	Arg 69	variant
Gly 233	-	expression tag
Thr 234	-	expression tag
Lys 235	-	expression tag
His 236	-	expression tag
His 237	-	expression tag
His 238	-	expression tag
His 239	-	expression tag
His 240	-	expression tag
His 241	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	100208.6
Branched	Number of molecules	1
	Total formula weight	471.4
Non-Polymers*	Number of molecules	16
	Total formula weight	3425.3
All*	Total formula weight	104105.2

*Water molecules are not included.