5J03

Crystal Structure of a chimeric Kv7.2 - Kv7.3 proximal C-terminal Domain in Complex with Calmodulin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Potassium voltage-gated channel subfamily KQT member 3,Potassium voltage-gated channel subfamily KQT member 2	polymer	110	13066.9	1	UniProt (O43525) UniProt (O43526)	Homo sapiens (Human)	KQT-like 3,Potassium channel subunit alpha KvLQT3,Voltage-gated potassium channel subunit Kv7.3,KQT-like 2,Neuroblastoma-specific potassium channel subunit alpha KvLQT2,Voltage-gated potassium channel subunit Kv7.2
2	B (B)	Calmodulin	polymer	149	16852.5	1	UniProt (P62158) Pfam (PF13499) UniProt (by SIFTS) (P0DP23)	Homo sapiens (Human)	CaM
3	C, D, E, F, G (B)	CALCIUM ION	non-polymer		40.1	5	Chemie (CA)
4	H (B)	ACETATE ION	non-polymer		59.0	1	Chemie (ACT)
5	I, J (A, B)	water	water		18.0	133	Chemie (HOH)

Sequence modifications

A: 343 - 529 (UniProt: O43525)

PDB	External Database	Details
Met 317	-	initiating methionine
Gly 318	-	expression tag
Ser 319	-	expression tag
His 320	-	expression tag
His 321	-	expression tag
His 322	-	expression tag
His 323	-	expression tag
His 324	-	expression tag
His 325	-	expression tag
His 326	-	expression tag
His 327	-	expression tag
Gly 328	-	expression tag
Ser 329	-	expression tag
Asp 330	-	expression tag
Tyr 331	-	expression tag
Asp 332	-	expression tag
Ile 333	-	expression tag
Pro 334	-	expression tag
Thr 335	-	expression tag
Thr 336	-	expression tag
Glu 337	-	expression tag
Asn 338	-	expression tag
Leu 339	-	expression tag
Tyr 340	-	expression tag
Phe 341	-	expression tag
Gln 342	-	expression tag
Ser 344	Leu 235	conflict

A: 530 - 557 (UniProt: O43526)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	29919.4
Non-Polymers*	Number of molecules	6
	Total formula weight	259.4
All*	Total formula weight	30178.9

*Water molecules are not included.