5IXK
RORgamma in complex with inverse agonist BIO399.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Nuclear receptor ROR-gamma | polymer | 228 | 26557.7 | 2 | UniProt (P51449) Pfam (PF00104) In PDB | Homo sapiens (Human) | Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma |
| 2 | A, B | N-(5-ethyl-3,3-dimethyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepin-8-yl)-3,4-dimethyl-N-(2,2,2-trifluoroethyl)benzene-1-sulfonamide | non-polymer | 484.5 | 2 | Chemie (6EW) | |||
| 3 | water | water | 18.0 | 39 | Chemie (HOH) |
Sequence modifications
A, B: 268 - 487 (UniProt: P51449)
| PDB | External Database | Details |
|---|---|---|
| Gly 260 | - | expression tag |
| Pro 261 | - | expression tag |
| Thr 262 | - | expression tag |
| Pro 263 | - | expression tag |
| Glu 264 | - | expression tag |
| Ala 265 | - | expression tag |
| Pro 266 | - | expression tag |
| Tyr 267 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 53115.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 969.1 | |
| All* | Total formula weight | 54084.4 |
