5ISA
Crystal structure of mouse CARM1 in complex with inhibitor SA0401
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (C, D, A, B) | Histone-arginine methyltransferase CARM1 | polymer | 364 | 41238.9 | 4 | UniProt (Q9WVG6) Pfam (PF06325) Pfam (PF22528) | Mus musculus (House Mouse) | Coactivator-associated arginine methyltransferase 1,Protein arginine N-methyltransferase 4 |
| 2 | E, J, M, S (C, D, A, B) | (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(3-azidopropyl)amino]-2-azanyl-butanoic acid | non-polymer | 450.5 | 4 | Chemie (6D5) | |||
| 3 | F, G, K, L, N... (C, D, A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 8 | Chemie (EDO) | |||
| 4 | H, I, P (C, A) | 1,2-DIMETHOXYETHANE | non-polymer | 90.1 | 3 | Chemie (DXE) | |||
| 5 | Q (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 6 | R (A) | 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE | non-polymer | 134.2 | 1 | Chemie (M2M) | |||
| 7 | V (B) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 8 | W (B) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 9 | AA, X, Y, Z (B, C, D, A) | water | water | 18.0 | 330 | Chemie (HOH) |
Sequence modifications
C, D, A, B: 130 - 490 (UniProt: Q9WVG6)
| PDB | External Database | Details |
|---|---|---|
| Gly 127 | - | expression tag |
| His 128 | - | expression tag |
| Met 129 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 164955.4 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 3026.2 | |
| All* | Total formula weight | 167981.6 |
