5IS9
Crystal structure of mouse CARM1 in complex with inhibitor SA0375
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Histone-arginine methyltransferase CARM1 | polymer | 361 | 40850.5 | 4 | UniProt (Q9WVG6) Pfam (PF06325) Pfam (PF22528) | Mus musculus (Mouse) | Coactivator-associated arginine methyltransferase 1,Protein arginine N-methyltransferase 4 |
| 2 | BA, E, P, V (D, A, B, C) | (2S)-2-amino-4-[(3-{4-[(2S)-2-amino-2-carboxyethyl]-1H-1,2,3-triazol-1-yl}propyl){[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}amino]butanoic acid (non-preferred name) | non-polymer | 563.6 | 4 | Chemie (6D3) | |||
| 3 | AA, CA, DA, EA, F... (C, D, A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 16 | Chemie (EDO) | |||
| 4 | FA, K, L, T (D, A, B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 4 | Chemie (PEG) | |||
| 5 | M, N (A) | 1,2-DIMETHOXYETHANE | non-polymer | 90.1 | 2 | Chemie (DXE) | |||
| 6 | O (A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 7 | U (B) | 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE | non-polymer | 134.2 | 1 | Chemie (M2M) | |||
| 8 | GA, HA, IA, JA (A, B, C, D) | water | water | 18.0 | 511 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 130 - 487 (UniProt: Q9WVG6)
| PDB | External Database | Details |
|---|---|---|
| Gly 127 | - | expression tag |
| His 128 | - | expression tag |
| Met 129 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 163401.8 | |
| Non-Polymers* | Number of molecules | 28 |
| Total formula weight | 4180.5 | |
| All* | Total formula weight | 167582.3 |
