5IOQ

Flavin-dependent thymidylate synthase in complex with FAD and deoxyuridine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Thymidylate synthase ThyX	polymer	232	27503.7	4	UniProt (Q9WYT0) Pfam (PF02511)	Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)	TSase
2	E, K, P, U (A, B, C, D)	FLAVIN-ADENINE DINUCLEOTIDE	non-polymer		785.5	4	Chemie (FAD)
3	F, G, H, I, J... (A, B, C)	TRIETHYLENE GLYCOL	non-polymer		150.2	10	Chemie (PGE)
4	L, M, Q, V (B, C, D)	2'-DEOXYURIDINE	non-polymer		228.2	4	Chemie (DUR)
5	W, X, Y, Z (A, B, C, D)	water	water		18.0	186	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 220 (UniProt: Q9WYT0)

PDB	External Database	Details
Met -11	-	initiating methionine
Gly -10	-	expression tag
Ser -9	-	expression tag
Asp -8	-	expression tag
Lys -7	-	expression tag
Ile -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	110014.7
Non-Polymers*	Number of molecules	18
	Total formula weight	5556.7
All*	Total formula weight	115571.5

*Water molecules are not included.