5IMX
Anaplastic lymphoma kinase (ALK) catalytic domain complexed with novel inhibitor 3-sulfonylpyrazol-4-amino pyrimidine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | ALK tyrosine kinase receptor | polymer | 327 | 36909.4 | 1 | UniProt (Q9UM73) Pfam (PF07714) In PDB | Homo sapiens (Human) | Anaplastic lymphoma kinase |
| 2 | A | 5-chloro-N~2~-{5-methyl-4-(1-methylpiperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N~4~-{1-methyl-3-[(propan-2-yl)sulfonyl]-1H-pyrazol-4-yl}pyrimidine-2,4-diamine | non-polymer | 576.2 | 1 | Chemie (CZ4) | |||
| 3 | water | water | 18.0 | 30 | Chemie (HOH) |
Sequence modifications
A: 1093 - 1411 (UniProt: Q9UM73)
| PDB | External Database | Details |
|---|---|---|
| Met 1085 | - | expression tag |
| Ala 1086 | - | expression tag |
| His 1087 | - | expression tag |
| His 1088 | - | expression tag |
| His 1089 | - | expression tag |
| His 1090 | - | expression tag |
| His 1091 | - | expression tag |
| His 1092 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36909.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 576.2 | |
| All* | Total formula weight | 37485.5 |
