5IFE
Crystal structure of the human SF3b core complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Splicing factor 3B subunit 5 | polymer | 86 | 10149.4 | 1 | UniProt (Q9BWJ5) Pfam (PF07189) | Homo sapiens (Human) | SF3b5,Pre-mRNA-splicing factor SF3b 10 kDa subunit |
| 2 | B (C) | Splicing factor 3B subunit 1 | polymer | 1304 | 146024.9 | 1 | UniProt (O75533) Pfam (PF08920) Pfam (PF22646) | Homo sapiens (Human) | Pre-mRNA-splicing factor SF3b 155 kDa subunit,SF3b155,Spliceosome-associated protein 155,SAP 155 |
| 3 | C (D) | PHD finger-like domain-containing protein 5A | polymer | 120 | 13308.5 | 1 | UniProt (Q7RTV0) Pfam (PF03660) | Homo sapiens (Human) | PHD finger-like domain protein 5A,Splicing factor 3B-associated 14 kDa protein,SF3b14b |
| 4 | D (A) | Splicing factor 3B subunit 3 | polymer | 1235 | 137791.0 | 1 | UniProt (Q15393) Pfam (PF10433) Pfam (PF03178) | Homo sapiens (Human) | Pre-mRNA-splicing factor SF3b 130 kDa subunit,SF3b130,STAF130,Spliceosome-associated protein 130,SAP 130 |
| 5 | E, F, G (D) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 6 | H (A) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) |
Sequence modifications
D: 1 - 110 (UniProt: Q7RTV0)
A: 1 - 1217 (UniProt: Q15393)
| PDB | External Database | Details |
|---|---|---|
| Gly -9 | - | expression tag |
| Pro -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Ser -5 | - | expression tag |
| Pro -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Arg -1 | - | expression tag |
| Ala 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -9 | - | expression tag |
| Ala -8 | - | expression tag |
| Glu -7 | - | expression tag |
| Phe -6 | - | expression tag |
| Lys -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Leu -3 | - | expression tag |
| Arg -2 | - | expression tag |
| Val -1 | - | expression tag |
| Asp 0 | - | expression tag |
| Asp 1218 | - | expression tag |
| Tyr 1219 | - | expression tag |
| Lys 1220 | - | expression tag |
| Asp 1221 | - | expression tag |
| Asp 1222 | - | expression tag |
| Asp 1223 | - | expression tag |
| Asp 1224 | - | expression tag |
| Lys 1225 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 307273.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 235.3 | |
| All* | Total formula weight | 307509.2 |
