5IDP

CDK8-CYCC IN COMPLEX WITH (3-Amino-1H-indazol-5-yl)-[(S)-2-(4-fluoro-phenyl)-piperidin-1-yl]-methanone

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Cyclin-dependent kinase 8	polymer	370	43247.1	1	UniProt (P49336) Pfam (PF00069) In PDB	Homo sapiens (Human)	Cell division protein kinase 8,Mediator complex subunit CDK8,Mediator of RNA polymerase II transcription subunit CDK8,Protein kinase K35
2	B	Cyclin-C	polymer	268	31771.3	1	UniProt (P24863) Pfam (PF00134) Pfam (PF16899) In PDB	Homo sapiens (Human)	SRB11 homolog,hSRB11
3	A	(3-amino-1H-indazol-5-yl)[(2S)-2-(4-fluorophenyl)piperidin-1-yl]methanone	non-polymer		338.4	1	Chemie (6A6)
4	A, B	FORMIC ACID	non-polymer		46.0	5	Chemie (FMT)
5		water	water		18.0	66	Chemie (HOH)

Sequence modifications

A: 1 - 364 (UniProt: P49336)

PDB	External Database	Details
Asp -1	-	expression tag
Lys 0	-	expression tag
Pro 365	-	expression tag
Leu 366	-	expression tag
Lys 367	-	expression tag
Lys 368	-	expression tag

B: 1 - 264 (UniProt: P24863)

PDB	External Database	Details
Asp -3	-	expression tag
Asp -2	-	expression tag
Lys -1	-	expression tag
Ala 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	75018.4
Non-Polymers*	Number of molecules	6
	Total formula weight	568.5
All*	Total formula weight	75586.9

*Water molecules are not included.