5IDN

CDK8-CYCC IN COMPLEX WITH [(S)-2-(4-Chloro-phenyl)-pyrrolidin-1-yl]-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-methanone

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Cyclin-dependent kinase 8	polymer	370	43247.1	1	UniProt (P49336) UniProt (by SIFTS) (P49336-2) In PDB	Homo sapiens (Human)	Cell division protein kinase 8,Mediator complex subunit CDK8,Mediator of RNA polymerase II transcription subunit CDK8,Protein kinase K35
2	B	Cyclin-C	polymer	267	31656.2	1	UniProt (P24863) Pfam (PF00134) Pfam (PF16899) In PDB	Homo sapiens (Human)	SRB11 homolog,hSRB11
3	A	[(2S)-2-(4-chlorophenyl)pyrrolidin-1-yl](3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone	non-polymer		340.8	1	Chemie (6A7)
4	A	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
5	A, B	FORMIC ACID	non-polymer		46.0	6	Chemie (FMT)
6		water	water		18.0	187	Chemie (HOH)

Sequence modifications

A: 1 - 364 (UniProt: P49336)

PDB	External Database	Details
Asp -1	-	expression tag
Lys 0	-	expression tag
Pro 365	-	expression tag
Leu 366	-	expression tag
Lys 367	-	expression tag
Lys 368	-	expression tag

B: 1 - 264 (UniProt: P24863)

PDB	External Database	Details
Asp -2	-	expression tag
Lys -1	-	expression tag
Ala 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	74903.3
Non-Polymers*	Number of molecules	8
	Total formula weight	679.0
All*	Total formula weight	75582.3

*Water molecules are not included.