5IBS

Structure of E76Q, a Cancer-Associated Mutation of the Oncogenic Phosphatase SHP2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Tyrosine-protein phosphatase non-receptor type 11	polymer	526	60334.1	2	UniProt (Q06124) Pfam (PF00017) Pfam (PF00102)	Homo sapiens (Human)	Protein-tyrosine phosphatase 1D,PTP-1D,Protein-tyrosine phosphatase 2C,PTP-2C,SH-PTP2,Shp2,SH-PTP3
2	C, D (A, B)	water	water		18.0	396	Chemie (HOH)

Sequence modifications

A, B: 1 - 525 (UniProt: Q06124)

PDB	External Database	Details
Ser 0	-	expression tag
Gln 76	Glu 76	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	120668.1
All*	Total formula weight	120668.1

*Water molecules are not included.