5IA4
Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with foretinib (XL880)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Ephrin type-A receptor 2 | polymer | 306 | 34462.8 | 1 | UniProt (P29317) Pfam (PF07714) In PDB | Homo sapiens (Human) | Epithelial cell kinase,Tyrosine-protein kinase receptor ECK |
2 | A | N-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | non-polymer | 632.7 | 1 | Chemie (88Z) | Homo sapiens | ||
3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | Homo sapiens | ||
4 | water | water | 18.0 | 131 | Chemie (HOH) |
Sequence modifications
A: 596 - 900 (UniProt: P29317)
PDB | External Database | Details |
---|---|---|
Gly 595 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 34462.8 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 694.7 | |
All* | Total formula weight | 35157.6 |