5I7M
Crystal structure of Y345F mutant of human primase p58 iron-sulfur cluster domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | DNA primase large subunit | polymer | 188 | 21709.9 | 2 | UniProt (P49643) Pfam (PF04104) | Homo sapiens (Human) | Primase regulatory subunit, DNA primase 58 kDa subunit, p58 |
| 2 | C, E (A, B) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 2 | Chemie (SF4) | |||
| 3 | D (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 103 | Chemie (HOH) |
Sequence modifications
A, B: 272 - 457 (UniProt: P49643)
| PDB | External Database | Details |
|---|---|---|
| Pro 270 | - | expression tag |
| Asn 271 | - | expression tag |
| Phe 345 | Tyr 345 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43419.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 799.3 | |
| All* | Total formula weight | 44219.1 |
