5I75
X-ray structure of the ts3 human serotonin transporter complexed with s-citalopram at the central site and Br-citalopram at the allosteric site
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Sodium-dependent serotonin transporter | polymer | 549 | 61689.8 | 1 | UniProt (P31645) Pfam (PF00209) In PDB | Homo sapiens (Human) | SERT,5HT transporter,5HTT,Solute carrier family 6 member 4 |
| 2 | B | 8B6 antibody, heavy chain | polymer | 221 | 23688.4 | 1 | Mus musculus | ||
| 3 | C | 8B6 antibody, light chain | polymer | 214 | 23718.2 | 1 | Mus musculus | ||
| 4 | A | (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile | non-polymer | 324.4 | 1 | Chemie (68P) | |||
| 5 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 6 | A | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) | |||
| 7 | A | TETRADECANE | non-polymer | 198.4 | 1 | Chemie (C14) | |||
| 8 | A | (1S)-1-(4-bromophenyl)-1-[3-(dimethylamino)propyl]-1,3-dihydro-2-benzofuran-5-carbonitrile | non-polymer | 385.3 | 1 | Chemie (69D) | |||
| 9 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) |
Sequence modifications
A: 76 - 618 (UniProt: P31645)
| PDB | External Database | Details |
|---|---|---|
| Gly 74 | - | cloning artifact |
| Ser 75 | - | cloning artifact |
| Ala 291 | Ile 291 | engineered mutation |
| Ser 439 | Thr 439 | engineered mutation |
| Ala 554 | Cys 554 | engineered mutation |
| Ala 580 | Cys 580 | engineered mutation |
| Leu 619 | - | cloning artifact |
| Val 620 | - | cloning artifact |
| Pro 621 | - | cloning artifact |
| Arg 622 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 109096.3 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1760.1 | |
| All* | Total formula weight | 110856.5 |
