5I5Z

CDK8-CYCC IN COMPLEX WITH 8-(1-Methyl-2,2-dioxo-2,3-dihydro-1H-2l6-benzo[c]isothiazol-5-yl)-[1,6]naphthyridine-2-carboxylic acid methylamide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Cyclin-dependent kinase 8	polymer	370	43233.0	1	UniProt (P49336) Pfam (PF00069) In PDB	Homo sapiens (Human)	Cell division protein kinase 8,Mediator complex subunit CDK8,Mediator of RNA polymerase II transcription subunit CDK8,Protein kinase K35
2	B	Cyclin-C	polymer	266	31541.1	1	UniProt (P24863) Pfam (PF00134) Pfam (PF16899) In PDB	Homo sapiens (Human)	SRB11 homolog,hSRB11
3	A	N-methyl-8-(1-methyl-2,2-dioxo-2,3-dihydro-1H-2lambda~6~,1-benzothiazol-5-yl)-1,6-naphthyridine-2-carboxamide	non-polymer		368.4	1	Chemie (68U)
4	A, B	FORMIC ACID	non-polymer		46.0	2	Chemie (FMT)
5		water	water		18.0	49	Chemie (HOH)

Sequence modifications

A: 1 - 362 (UniProt: P49336)

PDB	External Database	Details
Asp -2	-	expression tag
Asp -1	-	expression tag
Lys 0	-	expression tag
Pro 363	-	expression tag
Pro 364	-	expression tag
Leu 365	-	expression tag
Lys 366	-	expression tag
Lys 367	-	expression tag

B: 1 - 264 (UniProt: P24863)

PDB	External Database	Details
Lys -1	-	expression tag
Ala 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	74774.2
Non-Polymers*	Number of molecules	3
	Total formula weight	460.5
All*	Total formula weight	75234.6

*Water molecules are not included.