5I5Z
CDK8-CYCC IN COMPLEX WITH 8-(1-Methyl-2,2-dioxo-2,3-dihydro-1H-2l6-benzo[c]isothiazol-5-yl)-[1,6]naphthyridine-2-carboxylic acid methylamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cyclin-dependent kinase 8 | polymer | 370 | 43233.0 | 1 | UniProt (P49336) Pfam (PF00069) | Homo sapiens (Human) | Cell division protein kinase 8,Mediator complex subunit CDK8,Mediator of RNA polymerase II transcription subunit CDK8,Protein kinase K35 |
| 2 | B (B) | Cyclin-C | polymer | 266 | 31541.1 | 1 | UniProt (P24863) Pfam (PF00134) Pfam (PF16899) | Homo sapiens (Human) | SRB11 homolog,hSRB11 |
| 3 | C (A) | N-methyl-8-(1-methyl-2,2-dioxo-2,3-dihydro-1H-2lambda~6~,1-benzothiazol-5-yl)-1,6-naphthyridine-2-carboxamide | non-polymer | 368.4 | 1 | Chemie (68U) | |||
| 4 | D, E (A, B) | FORMIC ACID | non-polymer | 46.0 | 2 | Chemie (FMT) | |||
| 5 | F, G (A, B) | water | water | 18.0 | 49 | Chemie (HOH) |
Sequence modifications
A: 1 - 362 (UniProt: P49336)
B: 1 - 264 (UniProt: P24863)
| PDB | External Database | Details |
|---|---|---|
| Asp -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Lys 0 | - | expression tag |
| Pro 363 | - | expression tag |
| Pro 364 | - | expression tag |
| Leu 365 | - | expression tag |
| Lys 366 | - | expression tag |
| Lys 367 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Lys -1 | - | expression tag |
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 74774.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 460.5 | |
| All* | Total formula weight | 75234.6 |
