5I5K
Structure of complement C5 in complex with eculizumab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (B, A) | Complement C5 | polymer | 1676 | 188512.1 | 2 | UniProt (P01031) Pfam (PF17790) Pfam (PF07677) Pfam (PF01759) Pfam (PF01835) Pfam (PF17791) Pfam (PF17789) Pfam (PF07703) Pfam (PF01821) Pfam (PF00207) Pfam (PF07678) Pfam (PF21309) | Homo sapiens (Human) | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 |
| 2 | B, E (H, X) | Eculizumab heavy chain (variable domain) | polymer | 230 | 24860.8 | 2 | Homo sapiens (Human) | ||
| 3 | C, F (L, Y) | Eculizumab light chain (variable domain) | polymer | 214 | 23154.7 | 2 | Homo sapiens (Human) | ||
| 4 | G, H (C, D) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 473055.1 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1173.1 | |
| All* | Total formula weight | 474228.2 |
