5I3R
Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | BMP-2-inducible protein kinase | polymer | 302 | 34014.2 | 2 | UniProt (Q9NSY1) Pfam (PF00069) | Homo sapiens (Human) | BIKe |
| 2 | C, E (A, B) | N-[6-(3-{[(cyclopropylmethyl)sulfonyl]amino}phenyl)-1H-indazol-3-yl]cyclopropanecarboxamide | non-polymer | 410.5 | 2 | Chemie (IDK) | |||
| 3 | D, F (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 192 | Chemie (HOH) |
Sequence modifications
A, B: 42 - 343 (UniProt: Q9NSY1)
| PDB | External Database | Details |
|---|---|---|
| Ala 320 | Lys 320 | engineered mutation |
| Ala 321 | Lys 321 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 68028.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1010.9 | |
| All* | Total formula weight | 69039.3 |
