5I2N
Structure of the human GluN1/GluN2A LBD in complex with N-ethyl-7-{[2-fluoro-3-(trifluoromethyl)phenyl]methyl}-2-methyl-5-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-3-carboxamide (compound 29)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Glutamate receptor ionotropic, NMDA 2A | polymer | 285 | 31883.4 | 1 | UniProt (Q12879) Pfam (PF10613) Pfam (PF00060) In PDB | Homo sapiens (Human) | GluN2A, Glutamate [NMDA] receptor subunit epsilon-1, N-methyl D-aspartate receptor subtype 2A, hNR2A |
2 | B | Glutamate receptor ionotropic, NMDA 1 | polymer | 293 | 33409.1 | 1 | UniProt (Q05586) Pfam (PF10613) Pfam (PF00060) In PDB | Homo sapiens (Human) | GluN1, Glutamate [NMDA] receptor subunit zeta-1,N-methyl-D-aspartate receptor subunit NR1, NMD-R1 |
3 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
4 | A | GLUTAMIC ACID | non-polymer | 147.1 | 1 | Chemie (GLU) | |||
5 | A | N-ethyl-7-{[2-fluoro-3-(trifluoromethyl)phenyl]methyl}-2-methyl-5-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-3-carboxamide | non-polymer | 413.4 | 1 | Chemie (67J) | |||
6 | B | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
7 | B | GLYCINE | non-polymer | 75.1 | 1 | Chemie (GLY) | |||
8 | water | water | 18.0 | 295 | Chemie (HOH) |
Sequence modifications
A: 3 - 141 (UniProt: Q12879)
A: 144 - 285 (UniProt: Q12879)
B: 3 - 153 (UniProt: Q05586)
B: 156 - 293 (UniProt: Q05586)
PDB | External Database | Details |
---|---|---|
Gly 1 | - | expression tag |
Ser 2 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 142 | - | linker |
Thr 143 | - | linker |
PDB | External Database | Details |
---|---|---|
Gly 1 | - | expression tag |
Ser 2 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 154 | - | linker |
Thr 155 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 65292.5 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 914.0 | |
All* | Total formula weight | 66206.5 |