5I11
Crystal structure of the intertwined form of the Src tyrosine kinase SH3 domain T114S-Q128R mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Proto-oncogene tyrosine-protein kinase Src | polymer | 61 | 6920.5 | 1 | UniProt (P00523) Pfam (PF00018) | Gallus gallus (Chicken) | Proto-oncogene c-Src,pp60c-src,p60-Src |
| 2 | B (A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 3 | C (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | D, E (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 5 | F (A) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 6 | G (A) | water | water | 18.0 | 19 | Chemie (HOH) |
Sequence modifications
A: 85 - 141 (UniProt: P00523)
| PDB | External Database | Details |
|---|---|---|
| Gly 81 | - | expression tag |
| Ser 82 | - | expression tag |
| His 83 | - | expression tag |
| Met 84 | - | expression tag |
| Ser 114 | Thr 114 | engineered mutation |
| Arg 128 | Gln 128 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 6920.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 517.5 | |
| All* | Total formula weight | 7438.1 |
