5HYR
Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Stapled Peptide SRC2-SP2 and Estradiol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Estrogen receptor | polymer | 258 | 29242.4 | 2 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | C, D (F, G) | Stapled Peptide SRC2-SP2 | polymer | 13 | 1429.7 | 2 | UniProt (by SIFTS) (Q15596) | synthetic construct | |
| 3 | E, G (A, B) | ESTRADIOL | non-polymer | 272.4 | 2 | Chemie (EST) | |||
| 4 | F, H (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | I, J, K (A, B, F) | water | water | 18.0 | 158 | Chemie (HOH) |
Sequence modifications
A, B: 302 - 559 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 537 | Tyr 364 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 61344.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 729.0 | |
| All* | Total formula weight | 62073.2 |
