5HVY

CDK8/CYCC IN COMPLEX WITH COMPOUND 20

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Cyclin-dependent kinase 8	polymer	406	47105.9	1	UniProt (P49336) Pfam (PF00069) In PDB	Homo sapiens (Human)	Cell division protein kinase 8,Mediator complex subunit CDK8,Mediator of RNA polymerase II transcription subunit CDK8,Protein kinase K35
2	B	Cyclin-C	polymer	287	33710.1	1	UniProt (P24863) Pfam (PF00134) Pfam (PF16899) In PDB	Homo sapiens (Human)	SRB11 homolog,hSRB11
3	A	N-{(3S)-1-[2-(methylamino)pyrimidin-4-yl]pyrrolidin-3-yl}-N'-{4-[(morpholin-4-yl)methyl]-3-(trifluoromethyl)phenyl}urea	non-polymer		479.5	1	Chemie (66X)
4	A	FORMIC ACID	non-polymer		46.0	1	Chemie (FMT)
5	B	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
6		water	water		18.0	157	Chemie (HOH)

Sequence modifications

A: 1 - 403 (UniProt: P49336)

PDB	External Database	Details
Asp -2	-	expression tag
Asp -1	-	expression tag
Lys 0	-	expression tag

B: 1 - 283 (UniProt: P24863)

PDB	External Database	Details
Asp -3	-	expression tag
Asp -2	-	expression tag
Lys -1	-	expression tag
Ala 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	80816.0
Non-Polymers*	Number of molecules	4
	Total formula weight	596.4
All*	Total formula weight	81412.4

*Water molecules are not included.