5HVU

Rho-associated protein kinase 1 (ROCK 1) in complex with a pyridine thiazole piperidine inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Rho-associated protein kinase 1	polymer	415	48012.3	2	UniProt (Q13464) Pfam (PF00069)	Homo sapiens (Human)	Renal carcinoma antigen NY-REN-35,Rho-associated,coiled-coil-containing protein kinase 1,coiled-coil-containing protein kinase I,ROCK-I,p160 ROCK-1,p160ROCK
2	C, D (A, B)	2-{3-[3-(piperidin-4-yl)propoxy]phenyl}-N-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]acetamide	non-polymer		436.6	2	Chemie (65R)
3	E, F (A, B)	water	water		18.0	188	Chemie (HOH)

Sequence modifications

A, B: 6 - 415 (UniProt: Q13464)

PDB	External Database	Details
Gly 1	-	expression tag
Ser 2	-	expression tag
Leu 3	-	expression tag
His 4	-	expression tag
Met 5	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	96024.6
Non-Polymers*	Number of molecules	2
	Total formula weight	873.1
All*	Total formula weight	96897.7

*Water molecules are not included.