5HTI
Crystal structure of c-Met kinase domain in complex with LXM108
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Hepatocyte growth factor receptor | polymer | 319 | 36033.6 | 1 | UniProt (P08581) Pfam (PF07714) In PDB | Homo sapiens (Human) | HGF receptor,HGF/SF receptor,Proto-oncogene c-Met,Scatter factor receptor,SF receptor,Tyrosine-protein kinase Met |
2 | A | N-[3-fluoro-4-({7-[2-(morpholin-4-yl)ethoxy]-1,6-naphthyridin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | non-polymer | 589.6 | 1 | Chemie (66L) | |||
3 | water | water | 18.0 | 215 | Chemie (HOH) |
Sequence modifications
A: 1038 - 1346 (UniProt: P08581)
PDB | External Database | Details |
---|---|---|
Met 1028 | - | initiating methionine |
Gly 1029 | - | expression tag |
Ser 1030 | - | expression tag |
Ser 1031 | - | expression tag |
His 1032 | - | expression tag |
His 1033 | - | expression tag |
His 1034 | - | expression tag |
His 1035 | - | expression tag |
His 1036 | - | expression tag |
His 1037 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 36033.6 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 589.6 | |
All* | Total formula weight | 36623.2 |