5HRX
Crystal structure of the fifth bromodomain of human PB1 in complex with 1-butylisochromeno[3,4-c]pyrazol-5(2H)-one) compound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Protein polybromo-1 | polymer | 124 | 14648.0 | 2 | UniProt (Q86U86) Pfam (PF00439) | Homo sapiens (Human) | hPB1,BRG1-associated factor 180,BAF180,Polybromo-1D,PB1 fifth bromodomain |
| 2 | C, D (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 3 | E, F (A, B) | 1-butylisochromeno[3,4-c]pyrazol-5(3H)-one | non-polymer | 242.3 | 2 | Chemie (64F) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 75 | Chemie (HOH) |
Sequence modifications
A, B: 645 - 766 (UniProt: Q86U86)
| PDB | External Database | Details |
|---|---|---|
| Ser 643 | - | expression tag |
| Met 644 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29296.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 608.7 | |
| All* | Total formula weight | 29904.7 |
