5HQ2
Structural model of Set8 histone H4 Lys20 methyltransferase bound to nucleosome core particle
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone H3.2 | polymer | 135 | 15303.9 | 1 | UniProt (P84233) Pfam (PF00125) | Xenopus laevis (African clawed frog) | |
| 2 | B (B) | Histone H4 | polymer | 102 | 11263.2 | 1 | UniProt (P62799) Pfam (PF15511) | Xenopus laevis (African clawed frog) | |
| 3 | C (G) | Histone H2A | polymer | 129 | 13978.2 | 1 | UniProt (Q6AZJ8) Pfam (PF00125) Pfam (PF16211) UniProt (by SIFTS) (P06897) | Xenopus laevis (African clawed frog) | |
| 4 | D (H) | Histone H2B 1.1 | polymer | 122 | 13524.8 | 1 | UniProt (P02281) Pfam (PF00125) | Xenopus laevis (African clawed frog) | H2B1.1 |
| 5 | E (I) | DNA (149-MER) | polymer | 149 | 45772.2 | 1 | synthetic construct | ||
| 6 | F (J) | DNA (149-MER) | polymer | 149 | 46212.4 | 1 | synthetic construct | ||
| 7 | G (K) | Guanine nucleotide exchange factor SRM1 | polymer | 483 | 53095.6 | 1 | UniProt (P21827) Pfam (PF13540) Pfam (PF00415) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Pheromone response pathway component SRM1,Pre-mRNA-processing protein 20,Regulator of chromosome condensation,Suppressor of receptor mutations 1,mRNA transport protein 1 |
| 8 | H (M) | N-lysine methyltransferase SETD8 | polymer | 202 | 23016.3 | 1 | UniProt (Q9NQR1) Pfam (PF00856) | Homo sapiens (Human) | H4-K20-HMTase SETD8,Histone-lysine N-methyltransferase SETD8,Lysine N-methyltransferase 5A,PR/SET domain-containing protein 07,PR/SET07,SET domain-containing protein 8 |
Sequence modifications
A: 1 - 135 (UniProt: P84233)
H: 1 - 122 (UniProt: P02281)
K: 2 - 480 (UniProt: P21827)
M: 153 - 352 (UniProt: Q9NQR1)
| PDB | External Database | Details |
|---|---|---|
| Ala 102 | Gly 103 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Thr 29 | Ser 33 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 151 | - | expression tag |
| Ser 152 | - | expression tag |
| Phe 347 | His 347 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 222166.6 | |
| All* | Total formula weight | 222166.6 |
