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5HQ2

Structural model of Set8 histone H4 Lys20 methyltransferase bound to nucleosome core particle

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AHistone H3.2polymer13515303.91UniProt (P84233)
Pfam (PF00125)
In PDB
Xenopus laevis (African clawed frog)
2BHistone H4polymer10211263.21UniProt (P62799)
Pfam (PF15511)
In PDB
Xenopus laevis (African clawed frog)
3GHistone H2Apolymer12913978.21UniProt (Q6AZJ8)
Pfam (PF00125)
Pfam (PF16211)
UniProt (by SIFTS) (P06897)
In PDB
Xenopus laevis (African clawed frog)
4HHistone H2B 1.1polymer12213524.81UniProt (P02281)
Pfam (PF00125)
In PDB
Xenopus laevis (African clawed frog)H2B1.1
5IDNA (149-MER)polymer14945772.21synthetic construct
6JDNA (149-MER)polymer14946212.41synthetic construct
7KGuanine nucleotide exchange factor SRM1polymer48353095.61UniProt (P21827)
Pfam (PF13540)
Pfam (PF00415)
In PDB
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)Pheromone response pathway component SRM1,Pre-mRNA-processing protein 20,Regulator of chromosome condensation,Suppressor of receptor mutations 1,mRNA transport protein 1
8MN-lysine methyltransferase SETD8polymer20223016.31UniProt (Q9NQR1)
Pfam (PF00856)
In PDB
Homo sapiens (Human)H4-K20-HMTase SETD8,Histone-lysine N-methyltransferase SETD8,Lysine N-methyltransferase 5A,PR/SET domain-containing protein 07,PR/SET07,SET domain-containing protein 8
Sequence modifications
A: 1 - 135 (UniProt: P84233)
PDBExternal DatabaseDetails
Ala 102Gly 103conflict
H: 1 - 122 (UniProt: P02281)
PDBExternal DatabaseDetails
Thr 29Ser 33conflict
K: 2 - 480 (UniProt: P21827)
PDBExternal DatabaseDetails
Gly 0-expression tag
Ser 1-expression tag
M: 153 - 352 (UniProt: Q9NQR1)
PDBExternal DatabaseDetails
Gly 151-expression tag
Ser 152-expression tag
Phe 347His 347conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains8
Total formula weight222166.6
All*Total formula weight222166.6
*Water molecules are not included.

225158

PDB entries from 2024-09-18

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