5HP1
STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE In COMPLEX WITH A DNA aptamer and FOSCARNET, a Pyrophosphate analog
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT | polymer | 555 | 63875.1 | 2 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) | Pr160Gag-Pol |
2 | B, D | HIV-1 REVERSE TRANSCRIPTASE P51 SUBUNIT | polymer | 444 | 51928.6 | 2 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) | Pr160Gag-Pol |
3 | F, E | DNA (38-MER) | polymer | 38 | 11748.5 | 2 | synthetic construct | ||
4 | G, H | beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose | branched | 342.3 | 2 | In PDB BIRD (PRD_900003) | sucrose | ||
5 | A, C | MAGNESIUM ION | non-polymer | 24.3 | 8 | Chemie (MG) | |||
6 | A, C | PHOSPHONOFORMIC ACID | non-polymer | 126.0 | 2 | Chemie (PPF) | |||
7 | A, C | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
8 | B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
9 | F, E | 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE | non-polymer | 347.2 | 2 | Chemie (ATM) | |||
10 | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 555 (UniProt: P03366)
B, D: 1 - 428 (UniProt: P03366)
PDB | External Database | Details |
---|---|---|
Ser 280 | Cys 879 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -15 | - | initiating methionine |
Ala -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
Ala -7 | - | expression tag |
Leu -6 | - | expression tag |
Glu -5 | - | expression tag |
Val -4 | - | expression tag |
Leu -3 | - | expression tag |
Phe -2 | - | expression tag |
Gln -1 | - | expression tag |
Gly 0 | - | expression tag |
Ser 280 | Cys 879 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 255104.5 | |
Branched | Number of molecules | 2 |
Total formula weight | 684.6 | |
Non-Polymers* | Number of molecules | 16 |
Total formula weight | 1517.2 | |
All* | Total formula weight | 257306.3 |