5HNE
X-RAY CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL BRANCHED CHAIN AMINOTRANSFERASE (BCATM) COMPLEXED WITH A 2-ARYL BENZIMIDAZOLE COMPOUND AND AN INTERNAL ALDIMINE LINKED PLP COFACTOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Branched-chain-amino-acid aminotransferase, mitochondrial | polymer | 369 | 41725.4 | 2 | UniProt (O15382) Pfam (PF01063) | Homo sapiens (Human) | BCAT(m),Placental protein 18,PP18 |
| 2 | C, M (A, B) | PYRIDOXAL-5'-PHOSPHATE | non-polymer | 247.1 | 2 | Chemie (PLP) | |||
| 3 | D, N (A, B) | 1-[(1R,3S)-3-{[(5-bromothiophen-2-yl)carbonyl]amino}cyclohexyl]-N-methyl-2-(pyridin-2-yl)-1H-benzimidazole-5-carboxamide | non-polymer | 538.5 | 2 | Chemie (EL2) | |||
| 4 | E, O (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | F, G, H, I, J... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 9 | Chemie (EDO) | |||
| 6 | R (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | S, T (A, B) | water | water | 18.0 | 620 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 365 (UniProt: O15382)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| His -1 | - | expression tag |
| Met 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 83450.8 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 2292.8 | |
| All* | Total formula weight | 85743.6 |
