5HLZ

Structure of Pro-Activin A Complex at 2.85 A resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, F, G, H (A, C, E, G)	Inhibin beta A chain	polymer	270	30272.4	4	UniProt (P08476) Pfam (PF00688)	Homo sapiens (Human)	Activin beta-A chain,Erythroid differentiation protein,EDF
2	B, C, D, E (B, D, F, H)	Inhibin beta A chain	polymer	116	12991.9	4	UniProt (P08476) Pfam (PF00019)	Homo sapiens (Human)	Activin beta-A chain,Erythroid differentiation protein,EDF
3	I, J, K, L (A, C, E, G)	water	water		18.0	10	Chemie (HOH)

Sequence modifications

A, C, E, G: 30 - 305 (UniProt: P08476)

PDB	External Database	Details
Met 20	-	expression tag
Ser 21	-	expression tag
His 22	-	expression tag
His 23	-	expression tag
His 24	-	expression tag
His 25	-	expression tag
His 26	-	expression tag
His 27	-	expression tag
Ser 28	-	expression tag
Met 29	-	expression tag
Ser 35	Cys 35	engineered mutation
Ser 38	Cys 38	engineered mutation
-	Lys 259	deletion
-	Lys 260	deletion
-	Lys 261	deletion
-	Lys 262	deletion
-	Lys 263	deletion
-	Glu 264	deletion
-	Glu 265	deletion
-	Glu 266	deletion
-	Gly 267	deletion
-	Glu 268	deletion
-	Gly 269	deletion
-	Lys 270	deletion
-	Lys 271	deletion
-	Lys 272	deletion
-	Gly 273	deletion
-	Gly 274	deletion
-	Gly 275	deletion
-	Glu 276	deletion
-	Gly 277	deletion
-	Gly 278	deletion
-	Ala 279	deletion
-	Gly 280	deletion
-	Ala 281	deletion
-	Asp 282	deletion
Leu 306	-	cloning artifact
Glu 307	-	cloning artifact
Val 308	-	cloning artifact
Leu 309	-	cloning artifact
Phe 310	-	cloning artifact
Gln 310	-	cloning artifact
Gly 310	-	cloning artifact
Pro 310	-	cloning artifact

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	173057.2
All*	Total formula weight	173057.2

*Water molecules are not included.