5HJR
Murine endoplasmic reticulum alpha-glucosidase II with bound covalent intermediate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Neutral alpha-glucosidase AB | polymer | 857 | 97894.6 | 2 | UniProt (Q8BHN3) Pfam (PF13802) Pfam (PF01055) Pfam (PF21365) | Mus musculus (Mouse) | Alpha-glucosidase 2,Glucosidase II subunit alpha |
| 2 | B, D (B, D) | Glucosidase 2 subunit beta | polymer | 83 | 8912.6 | 2 | UniProt (O08795) Pfam (PF12999) | Mus musculus (Mouse) | 80K-H protein,Glucosidase II subunit beta,Protein kinase C substrate 60.1 kDa protein heavy chain,PKCSH |
| 3 | E (E) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
| 4 | F (F) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 5 | BA, BB, G, H, IA... (A, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | Mus musculus (House Mouse) | ||
| 6 | CA, EA, EB, HA, I... (A, B, D, C) | FORMIC ACID | non-polymer | 46.0 | 32 | Chemie (FMT) | Mus musculus (House Mouse) | ||
| 7 | W, YA (A, C) | 5-fluoro-beta-D-glucopyranose | non-polymer | 198.1 | 2 | Chemie (5GF) | |||
| 8 | CB, DA, Y, ZA (C, A) | HEXAETHYLENE GLYCOL | non-polymer | 282.3 | 4 | Chemie (P6G) | |||
| 9 | AB, DB, Z (C, A) | OXAMIC ACID | non-polymer | 89.0 | 3 | Chemie (OXM) | |||
| 10 | AA (A) | D(-)-TARTARIC ACID | non-polymer | 150.1 | 1 | Chemie (TAR) | |||
| 11 | FA, FB, GA, GB (B, D) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 12 | HB, IB, JB, KB (A, B, C, D) | water | water | 18.0 | 424 | Chemie (HOH) |
Sequence modifications
A, C: 33 - 944 (UniProt: Q8BHN3)
| PDB | External Database | Details |
|---|---|---|
| - | Val 186 | deletion |
| - | Pro 187 | deletion |
| - | Phe 188 | deletion |
| - | Ser 189 | deletion |
| - | Asp 190 | deletion |
| - | Lys 191 | deletion |
| - | Val 192 | deletion |
| - | Ser 193 | deletion |
| - | Leu 194 | deletion |
| - | Ala 195 | deletion |
| - | Leu 196 | deletion |
| - | Gly 197 | deletion |
| - | Ser 198 | deletion |
| - | Val 199 | deletion |
| - | Trp 200 | deletion |
| - | Asp 201 | deletion |
| - | Lys 202 | deletion |
| - | Ile 203 | deletion |
| - | Lys 204 | deletion |
| - | Asn 205 | deletion |
| - | Leu 206 | deletion |
| - | Phe 207 | deletion |
| - | Ser 208 | deletion |
| - | Arg 209 | deletion |
| - | Gln 210 | deletion |
| - | Glu 211 | deletion |
| - | Ser 212 | deletion |
| - | Lys 213 | deletion |
| - | Asp 214 | deletion |
| - | Pro 215 | deletion |
| - | Ala 216 | deletion |
| - | Glu 217 | deletion |
| - | Gly 218 | deletion |
| - | Asn 219 | deletion |
| - | Gly 220 | deletion |
| - | Ala 221 | deletion |
| - | Gln 222 | deletion |
| - | Pro 223 | deletion |
| - | Glu 224 | deletion |
| - | Ala 225 | deletion |
| - | Thr 226 | deletion |
| - | Pro 227 | deletion |
| - | Gly 228 | deletion |
| - | Asp 229 | deletion |
| - | Gly 230 | deletion |
| - | Asp 231 | deletion |
| - | Lys 232 | deletion |
| - | Pro 233 | deletion |
| - | Glu 234 | deletion |
| - | Glu 235 | deletion |
| - | Thr 236 | deletion |
| - | Gln 237 | deletion |
| - | Glu 238 | deletion |
| - | Lys 239 | deletion |
| - | Ala 240 | deletion |
| - | Glu 241 | deletion |
| - | Lys 242 | deletion |
| - | Asp 243 | deletion |
| - | Thr 351 | deletion |
| - | Ala 352 | deletion |
| - | Gly 353 | deletion |
| - | Lys 354 | deletion |
| - | Thr 355 | deletion |
| - | Leu 356 | deletion |
| - | Phe 357 | deletion |
| - | Gly 358 | deletion |
| - | Lys 359 | deletion |
| - | Met 360 | deletion |
| - | Leu 361 | deletion |
| - | Asp 362 | deletion |
| - | Tyr 363 | deletion |
| - | Leu 364 | deletion |
| - | Gln 365 | deletion |
| - | Gly 366 | deletion |
| - | Ser 367 | deletion |
| - | Gly 368 | deletion |
| - | Glu 369 | deletion |
| Thr 945 | - | expression tag |
| Ser 946 | - | expression tag |
| Val 947 | - | expression tag |
| Leu 948 | - | expression tag |
| Ile 949 | - | expression tag |
| Leu 950 | - | expression tag |
| Arg 951 | - | expression tag |
| Lys 952 | - | expression tag |
| Pro 953 | - | expression tag |
| Gly 954 | - | expression tag |
| Val 955 | - | expression tag |
| Ser 956 | - | expression tag |
| Val 957 | - | expression tag |
| Ala 958 | - | expression tag |
| Ser 959 | - | expression tag |
| Asp 960 | - | expression tag |
| Trp 961 | - | expression tag |
| Ser 962 | - | expression tag |
| Ile 963 | - | expression tag |
| His 964 | - | expression tag |
| Leu 965 | - | expression tag |
| Arg 966 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 213614.5 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1659.5 | |
| Non-Polymers* | Number of molecules | 53 |
| Total formula weight | 4010.4 | |
| All* | Total formula weight | 219284.5 |
