5HIE

BRAF Kinase domain b3aC loop deletion mutant in complex with dabrafenib

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Serine/threonine-protein kinase B-raf	polymer	302	34735.1	4	UniProt (P15056) Pfam (PF07714)	Homo sapiens (Human)	Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1
2	E, F, G, H (A, B, C, D)	Dabrafenib	non-polymer		519.6	4	Chemie (P06)
3	I, J, K, L (A, B, C, D)	water	water		18.0	49	Chemie (HOH)

Sequence modifications

A, B, C, D: 432 - 726 (UniProt: P15056)

PDB	External Database	Details
Met 420	-	initiating methionine
Asp 421	-	expression tag
Arg 422	-	expression tag
Gly 423	-	expression tag
Ser 424	-	expression tag
His 425	-	expression tag
His 426	-	expression tag
His 427	-	expression tag
His 428	-	expression tag
His 429	-	expression tag
His 430	-	expression tag
Gly 431	-	expression tag
-	Asn 486	deletion
-	Val 487	deletion
-	Thr 488	deletion
-	Ala 489	deletion
-	Pro 490	deletion

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	138940.4
Non-Polymers*	Number of molecules	4
	Total formula weight	2078.2
All*	Total formula weight	141018.7

*Water molecules are not included.