5HIE
BRAF Kinase domain b3aC loop deletion mutant in complex with dabrafenib
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Serine/threonine-protein kinase B-raf | polymer | 302 | 34735.1 | 4 | UniProt (P15056) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1 |
2 | A, B, C, D | Dabrafenib | non-polymer | 519.6 | 4 | Chemie (P06) | |||
3 | water | water | 18.0 | 49 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 432 - 726 (UniProt: P15056)
PDB | External Database | Details |
---|---|---|
Met 420 | - | initiating methionine |
Asp 421 | - | expression tag |
Arg 422 | - | expression tag |
Gly 423 | - | expression tag |
Ser 424 | - | expression tag |
His 425 | - | expression tag |
His 426 | - | expression tag |
His 427 | - | expression tag |
His 428 | - | expression tag |
His 429 | - | expression tag |
His 430 | - | expression tag |
Gly 431 | - | expression tag |
- | Asn 486 | deletion |
- | Val 487 | deletion |
- | Thr 488 | deletion |
- | Ala 489 | deletion |
- | Pro 490 | deletion |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 138940.4 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 2078.2 | |
All* | Total formula weight | 141018.7 |