5HHV
Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Interleukin-17A | polymer | 123 | 14235.9 | 2 | UniProt (Q16552) Pfam (PF06083) | Homo sapiens (Human) | IL-17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8 |
| 2 | C (H) | CAT-2000 FAB heavy chain | polymer | 237 | 25053.9 | 1 | Homo sapiens | ||
| 3 | D (I) | IL-17A peptide inhibitor | polymer | 16 | 1849.1 | 1 | Synthetic construct | ||
| 4 | E (L) | CAT-2000 FAB light chain | polymer | 214 | 23006.3 | 1 | Homo sapiens | ||
| 5 | F, G, H, I (A, H, I, L) | water | water | 18.0 | 51 | Chemie (HOH) |
Sequence modifications
A, B: 11 - 132 (UniProt: Q16552)
| PDB | External Database | Details |
|---|---|---|
| Asp 10 | - | expression tag |
| Asp 45 | Asn 68 | engineered mutation |
| Ser 106 | Cys 129 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 78381.3 | |
| All* | Total formula weight | 78381.3 |
